- Overactivation of the endocannabinoid system alters the antilipolytic action of insulin in mouse adipose tissue.
Overactivation of the endocannabinoid system alters the antilipolytic action of insulin in mouse adipose tissue.
American journal of physiology. Endocrinology and metabolism (2017-03-23)
Tania Muller, Laurent Demizieux, Stéphanie Troy-Fioramonti, Joseph Gresti, Jean-Paul Pais de Barros, Hélène Berger, Bruno Vergès, Pascal Degrace
PMID28325733
ANOTACE
Evidence has accumulated that obesity-related metabolic dysregulation is associated with overactivation of the endocannabinoid system (ECS), which involves cannabinoid receptor 1 (CB1R), in peripheral tissues, including adipose tissue (AT). The functional consequences of CB1R activation on AT metabolism remain unclear. Since excess fat mobilization is considered an important primary event contributing to the onset of insulin resistance, we combined in vivo and in vitro experiments to investigate whether activation of ECS could alter the lipolytic rate. For this purpose, the appearance of plasma glycerol was measured in wild-type and CB1R
MATERIÁLY