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Merck

The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke.

Nature communications (2011-09-29)
Kazuhiko Nakano, Kazuya Hokamura, Naho Taniguchi, Koichiro Wada, Chiho Kudo, Ryota Nomura, Ayuchi Kojima, Shuhei Naka, Yoshinori Muranaka, Min Thura, Atsushi Nakajima, Katsuhiko Masuda, Ichiro Nakagawa, Pietro Speziale, Nobumitsu Shimada, Atsuo Amano, Yoshinori Kamisaki, Tokutaro Tanaka, Kazuo Umemura, Takashi Ooshima
ANOTACE

Although several risk factors for stroke have been identified, one-third remain unexplained. Here we show that infection with Streptococcus mutans expressing collagen-binding protein (CBP) is a potential risk factor for haemorrhagic stroke. Infection with serotype k S. mutans, but not a standard strain, aggravates cerebral haemorrhage in mice. Serotype k S. mutans accumulates in the damaged, but not the contralateral hemisphere, indicating an interaction of bacteria with injured blood vessels. The most important factor for high-virulence is expression of CBP, which is a common property of most serotype k strains. The detection frequency of CBP-expressing S. mutans in haemorrhagic stroke patients is significantly higher than in control subjects. Strains isolated from haemorrhagic stroke patients aggravate haemorrhage in a mouse model, indicating that they are haemorrhagic stroke-associated. Administration of recombinant CBP causes aggravation of haemorrhage. Our data suggest that CBP of S. mutans is directly involved in haemorrhagic stroke.

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Sigma-Aldrich
Bacitracin, from Bacillus licheniformis, ≥65 IU/mg
Sigma-Aldrich
Bacitracin, from Bacillus licheniformis, ≥65 IU/mg