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Supramolecular sensor for cancer-associated nitrosamines.

Journal of the American Chemical Society (2012-12-01)
Tsuyoshi Minami, Nina A Esipenko, Ben Zhang, Maria E Kozelkova, Lyle Isaacs, Ryuhei Nishiyabu, Yuji Kubo, Pavel Anzenbacher
ANOTACE

A supramolecular assay based on two fluorescent cucurbit[n]uril probes enables the recognition and quantification of nitrosamines, including cancer-associated nitrosamines, compounds that are difficult to recognize. The cross-reactive sensor leverages weak interactions and competition among the probe, metal, and guest, yielding high information density in the signal output (variance) and enabling the recognition of structurally similar guests.

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Sigma-Aldrich
Cucurbit[6]uril hydrate, contains acid of crystalization