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Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences (2012-10-31)
Emma Puighermanal, Arnau Busquets-Garcia, Rafael Maldonado, Andrés Ozaita
ANOTACE

Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system.

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Arachidonylethanolamide, ≥97.0% (TLC), oil