Tetraethylene glycol diacrylate. A cause of delayed cutaneous irritant reaction and allergic contact dermatitis.

A woman who worked as a materials handler in a plant manufacturing acrylated chemicals developed allergic contact allergy to tetraethylene glycol diacrylate (TTEGDA). Four co-workers experienced skin irritation 12 to 36 hours after skin contact with TTEGDA but had no immediate reaction at the time of exposure. The chemical sensitized the albino guinea pig in the guinea pig maximization test. By varying parameters such as the administration of Freund's complete adjuvent, the intradermal concentration injected for induction, and the diluent used for the injections, it was possible to alter the apparent sensitization potential of TTEGDA.