- Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase.
Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase.
Bioorganic & medicinal chemistry (2011-05-11)
Mariya al-Rashida, Muhammad Ashraf, Bushra Hussain, Saeed Ahmad Nagra, Ghulam Abbas
PMID21555223
ANOTACE
Series of chromone containing sulfonamides were prepared by the reaction of (un)substituted 3-formylchromones with 3-aminobenzenesulfonamide and 4-aminobenzenesulfonamide. Bovine carbonic anhydrase (bCA) inhibitory activity of these newly synthesized compounds was determined. All compounds were active and possessed excellent bCA inhibitory activities with IC₅₀ values ranged between 4.31 ± 0.001 and 29.12 ± 0.008 μmol. Compounds derived from 6-fluoro-3-formylchromones were the most active.
MATERIÁLY