- An improved Bouveault-Blanc ester reduction with stabilized alkali metals.
An improved Bouveault-Blanc ester reduction with stabilized alkali metals.
The Journal of organic chemistry (2009-02-18)
Brian S Bodnar, Paul F Vogt
PMID19219971
ANOTACE
Significantly improved Bouveault-Blanc conditions for ester reduction have been developed using sodium in silica gel (Na-SG), a free-flowing powder that can be easily handled in the open atmosphere. Primary alcohols were prepared in excellent yield from a variety of aliphatic esters under mild reaction conditions. The chemistry presented here is far safer than the classic Bouveault-Blanc reduction and is competitive with more modern hydride reduction methods.
MATERIÁLY