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  • Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines.

Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines.

Organic & biomolecular chemistry (2012-03-10)
Viktor O Iaroshenko, Ingo Knepper, Muhammad Zahid, Rene Kuzora, Sergii Dudkin, Alexander Villinger, Peter Langer
ANOTACE

A facile synthetic approach for the synthesis of 1,8-naphthyridine-4(1H)-one derivatives via a catalyst free and Pd-supported tandem amination sequence is developed and described. In a case of aliphatic amines reaction proceeds in a catalyst free mode, however anilines demand Pd-supported reaction conditions.

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Sigma-Aldrich
4-(Trifluoromethyl)phenylboronic acid, ≥95.0%