SML3900

955, CDK9 PROTAC trifluoroacetate

≥98% (HPLC)

• Synonyma: (E)-N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(2-(4-(2-(2,6-dimethoxy-4-(3-oxo-3-(6-oxo-3,6-dihydropyridin-1(2H)-yl)prop-1-en-1-yl)phenoxy)ethyl)piperazin-1-yl)-2-oxoethyl)piperidine-4-carboxamide trifluoroacetate, PL-SNS-032 conjugate 955 trifluoroacetate
• Empirický vzorec (Hillův zápis): C₄₁H₅₃N₇O₈S₂ · xC₂HF₃O₂
• Molekulová hmotnost: 836.03 (free base basis)
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Vlastnosti

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Popis

Biochem/physiol Actions

955 CDK9 PROTAC is a cell penetrant conjugate of the CDK9 inhibitor SNS-032 with new recruiter of the E3 ligase KEAP1 piperlongumine that potently degrades CDK9 in MOLT4 cells. Similarly, to THAL-SNS-032, 955 induces CDK10 degradation. 955 exhibits potent antiproliferative activity in several prostate cancer cell lines including LNCaP, 22RV1, PC3 and DU145 cells.

Cell penetrant, potent and selective CDK9 degrader

Disclaimer

Hygroscopic

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable