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R121

Sigma-Aldrich

S(−)-Raclopride (+)-tartrate salt

>97%, solid

Synonyma:

3,5-Dichloro-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxybenzamide (+)-tartrate salt

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About This Item

Empirický vzorec (Hillův zápis):
C15H20Cl2N2O3 · C4H6O6
Číslo CAS:
98185-20-7
Molekulová hmotnost:
497.32
MDL number:
MFCD00274072
UNSPSC Code:
12352200
PubChem Substance ID:
24277931
NACRES:
NA.77

assay

>97%

form

solid

color

white

solubility

H2O: 89 mg/mL

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC

InChI

1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;5-1(3(7)8)2(6)4(9)10/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1

InChI key

QULBVRZTKPQGCR-NDAAPVSOSA-N

Gene Information

human ... DRD2(1813)

Application

S(−)-Raclopride (+)-tartrate salt has been used as a D2 receptor antagonist:
  • to study the role of the D2 receptor in mediating ventrolateral PAG (vlPAG)/dorsal raphe dopaminergic antinociceptive effect in animals
  • in pharmacological and behavioral studies performed with Thap1 null mice
  • to determine the relationship between Ca2+ transients and dopamine neuron activity in rats

Biochem/physiol Actions

Raclopride is a benzamide derivative and a selective D2 dopamine receptor antagonist.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Caution

Photosensitive

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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