M2378

Mucin from porcine stomach

Type II

• Synonyma: MUC
• Číslo CAS: 84082-64-4
• UNSPSC Code: 12352202
• EC Number: 282-010-7
• NACRES: NA.61
• MDL number: MFCD00131629
• Form: powder
• Biological source: Porcine stomach

Vlastnosti

• biological source: Porcine stomach
• Quality Segment: 200
• type: Type II
• form: powder
• composition: bound sialic acid, ≤1.2%
• technique(s): cell culture | mammalian: suitable
• solubility: 1 M NaOH: soluble 20 mg/mL
• UniProt accession no.: A0A5G2QSD1
• storage temp.: 2-8°C
• Gene Information: pig ... MUC2(100127145)

Popis

General description

Mucin is majorly composed of carbohydrate units, crucial for structural architecture and conformation. The monomer of mucin is 640 kDa, with protein contributing to only 20% of the molecular weight. The carbohydrate component is attached to the threonine and serine side chains. Mucins are classified into secreted and transmembrane mucins.

Mucins or mucus glycoproteins are the main macromolecular components of mammalian mucus. It was also used in a study to evaluate the sputum smears concentrated by cyto-centrifugation for detection of acid-fast bacilli.

Application

Mucin from porcine stomach has been used:

• in the standard curve generation for quantifying mucin-2 generated during mucosal inflammation in mice
• as a component of digestion fluid solutions in in vitro human digestion model
• as a component of simulated saliva fluid

Mucin from porcine stomach was used in studies on the binding site of the galactose-specific agglutinin PA-IL from Pseudomonas aeruginosa.

Biochem/physiol Actions

Mucin has wide pharmacological applications in drug delivery. Mucins play a protective role in inflammation. Deregulation in mucin synthesis contributes to tumorigenesis and chronic inflammation.

Mucus forms the protective cover for all epithelial surfaces. The major structural component of mucus is gel-forming mucins. The mucus layer covering the intestinal epithelium has the MUC2 mucin as its central molecule. MUC2 is produced by goblet cells.

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)