K4394

PKF118-310

≥98% (HPLC)

• Synonyma: 1,6-Dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, Toxoflavin, Xanthothricin
• Empirický vzorec (Hillův zápis): C₇H₇N₅O₂
• Číslo CAS: 84-82-2
• Molekulová hmotnost: 193.16
• NACRES: NA.77
• PubChem Substance ID: 329817147
• UNSPSC Code: 12352200
• MDL number: MFCD00459812
• Assay: ≥98% (HPLC)
• Form: powder

Vlastnosti

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: H₂O: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CN1N=CN=C(C1=N2)C(N(C)C2=O)=O
• InChI: 1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
• InChI key: SLGRAIAQIAUZAQ-UHFFFAOYSA-N

Popis

Biochem/physiol Actions

PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.

PKF118-310 is a Tcf4/b-catenin antagonist.

Bezpečnostní informace

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Skladovací třída: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable