H5160

Hyperforin

≥85% (HPLC), Use secondary activity, solution

• Empirický vzorec (Hillův zápis): C₃₅H₅₂O₄
• Číslo CAS: 11079-53-1
• Molekulová hmotnost: 536.78
• NACRES: NA.77
• PubChem Substance ID: 329815216
• UNSPSC Code: 12352200
• EC Number: 200-659-6
• MDL number: MFCD01861497
• Assay: ≥85% (HPLC)
• Form: solution

Vlastnosti

• Název produktu: Hyperforin, ≥85% (HPLC)
• Quality Segment: 100
• assay: ≥85% (HPLC)
• form: solution
• storage temp.: −20°C
• SMILES string: CC(C)C(=O)[C@@]12C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(/C)C)(C[C@H](C\C=C(\C)C)[C@@]1(C)CC\C=C(\C)C)C2=O
• InChI: 1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
• InChI key: IWBJJCOKGLUQIZ-HQKKAZOISA-N

Popis

General description

Hyperforin is a phloroglucinol component of St. John′s wort and a pregnane X receptor ligand.

Application

Hyperforin may be used:

• as a reference standard for calibration curve generation in high-perfornamce liquid chromatography (HPLC) analysis
• to test its cytotoxic effect and apoptosis induction in mouse embryonic cells
• as a pregnane X receptor (PXR) in porcine brain capillary endothelial cells for transport assay

Biochem/physiol Actions

Hyperforin is an active antidepressant and an inhibitor of cytochrome P450 3A4 (CYP3A). It elicits antioxidant and antibacterial activity. Hyperforin is also embryotoxic and inhibits tumor proliferation. It effectively inhibits dopamine, serotonin and norepinephrine.

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

Bezpečnostní informace

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes
• Skladovací třída: 3 - Flammable liquids
• wgk: WGK 2
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup
• ppe: Eyeshields, Gloves, type N95 (US)