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E4876

17α-Ethynylestradiol

Name: 17&#945;-Ethynylestradiol
Brand: SIGMA

≥98%, Synthetic estrogen, powder

Synonyma:

17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol, 19-Nor-1,3,5(10),17α-pregnatrien-20-yne-3,17-diol, Ethinylestradiol

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O této položce

Empirický vzorec (Hillův zápis):

C₂₀H₂₄O₂

Číslo CAS:

57-63-6

Molekulová hmotnost:

296.40

NACRES:

NA.77

PubChem Substance ID:

24894585

UNSPSC Code:

12352200

EC Number:

200-342-2

MDL number:

MFCD00003690

Beilstein/REAXYS Number:

2419975

Assay:

≥98%

Form:

powder

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Vlastnosti

Název produktu

17α-Ethynylestradiol, ≥98%

biological source

synthetic

sterility

non-sterile

assay

≥98%

form

powder

mp

182-183 °C (lit.)

solubility

ethanol: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24

InChI

1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1

InChI key

BFPYWIDHMRZLRN-SLHNCBLASA-N

Gene Information

human ... ESR1(2099)
rat ... Afp(24177), Esr1(24890), Shbg(24775)

Popis

General description

17α-Ethynylestradiol (EE2) is a synthetic hormone. It is a derivative of estradiol (E2). It is implicated in estrogen replacement therapy and suspension of breastfeeding. EE2 is used to treat osteoporosis, menopausal and postmenopausal syndrome. It is also used to treat prostatic cancer and breast cancer in postmenopausal women. EE2 functions as an endocrine-disrupting chemical (EDC).

Application

17α-Ethynylestradiol has been used to study the effect of exogenous estrogen and selective estrogen receptor modulator (SERM) in rats. It also has been used to increase the concentration of low density lipoprotein (LDL) receptor in rabbit liver.