D3695

DMOG

≥98% (HPLC), powder, HIF-hydroxylase inhibitor

• Synonyma: Dimethyloxalylglycine, N-(Methoxyoxoacetyl)-glycine methyl ester
• Empirický vzorec (Hillův zápis): C₆H₉NO₅
• Číslo CAS: 89464-63-1
• Molekulová hmotnost: 175.14
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798774
• NACRES: NA.77
• MDL number: MFCD05865098
• Assay: ≥98% (HPLC)
• Form: powder

Vlastnosti

• Název produktu: DMOG, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: H₂O: >30 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: COC(=O)CNC(=O)C(=O)OC
• InChI: 1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
• InChI key: BNJOZDZCRHCODO-UHFFFAOYSA-N

Popis

Application

DMOG has been used:

• in hypoxia-inducible factor (HIF) activity assay
• to examine its effects on the degradation of HIF-1α and renal regeneration
• in DMOG preconditioning of adipose tissues
• as vehicle control for the primary liquid culture of CD34⁺ cells
• for endothelial cell stimulation

Dimethyloxalylglycine (DMOG) has been used as an inhibitor of ten-eleven translocation 3 (TET3) protein.

Biochem/physiol Actions

DMOG is a cell permeable prolyl-4-hydroxylase inhibitor, which upregulates HIF (hypoxia-inducible factor).

DMOG is a cell permeable prolyl-4-hydroxylase inhibitor, which upregulates HIF (hypoxia-inducible factor). The protein level of HIF-1α subunit is post-transcriptionally regulated by prolyl and asparaginyl hydroxylase (PAH). Suppression of PAH activity increases endogenous HIF-1α levels. DMOG is a cell permeable, competitive inhibitor of prolyl hydroxylase domain-containing proteins (PHDs and HIF-PHs). It has been discovered that the DMOG posseses neuroprotective effect on NFG deprived cell cultures through preservation of glucose metabolism. DMOG also attenuates myocardial injury in a rabbit ischemia reperfusion model. DMOG is more potent than the older inhibitor 4-Phenyl-pyridine-2,5-dicarboxylic acid (R395889; Sigma-Aldrich rare chemicals library). The IC₅₀ is 5.18 μM.

Features and Benefits

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Bezpečnostní informace

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable