P3B010A10

Pellicon^® 3 Cassette with Biomax^® Membrane

10kDa, A Screen, 1.14 m², Holdup volume 134 mL

• Synonyma: Pellicon^® 3 Cassette with Biomax 10 kDa Membrane, A screen, 1.14 m², Pellicon^® 3 Biomax^® High-Flux Cassette, Pellicon^® 3 Biomax^® TFF Cassette
• eCl@ss: 32031623
• UNSPSC Code: 23151806

Vlastnosti

• Quality Segment: 400
• material: TPE seal, polyethersulfone , polypropylene screen, stainless steel cap (for end; polypropylene-encapsulated)
• product line: Pellicon^®
• feature: holdup volume 134 mL (in feed channel)
• manufacturer/tradename: Pellicon^®
• parameter: 30 psi max. reverse press. exposure at 25 °C (for 24 hours), 4-6 L/min-m² recirculation rate, 40 psi max. transmembrane pressure at 4-50 °C, 6.9 bar max. inlet pressure (100 psi), 80 psi max. transmembrane pressure at 4-40 °C
• technique(s): analytical sample preparation: suitable, buffer exchange: suitable, protein purification: suitable (concentration), tangential flow filtration (TFF): suitable
• H: 3.8 cm (1.51 in.)
• L: 20.6 cm (8.1 in.)
• W: 17.8 cm (7 in.)
• membrane nominal area: 1.14 m²
• gravimetric extractables: ≤1500 mg/m²
• matrix: Biomax^® (Membrane)
• pore size: 10 kDa NMWCO
• pH: 1-14
• application(s): mAb; recombinant protein

Popis

General description

Pellicon^® 3 cassette with Biomax^® membrane is a high performance tangential flow filtration (TFF) device designed for the concentration and diafiltration of therapeutic proteins and other biologics. This cassette is manufactured to support high titer and high viscosity feed streams. Its durable construction enables operation under demanding process conditions, including elevated pressures, temperatures, and rigorous cleaning protocols.

Application

Pellicon^® 3 Cassettes with Biomax^® 10kD Membrane A screen is designed for high mass transfer and excellent flux. These cassettes can achieve higher concentration therapeutic protein formulations by managing the pressure drop created by the feed stream. From process development through commercial production, these cassettes deliver reliable performance across various filtration applications, including:

• Monoclonal antibodies (mAbs)
• Recombinant proteins
• Growth factors
• Hormones
• Vaccine process streams
• High-fouling biological feed streams

Features and Benefits

• Robust, void-free membrane provides optimum product retention and performance consistency
• Unique feed screen design enables high mass transfer, flux for higher final concentration
• Fast, reliable scale up/down from lab to production scale
• Automated manufacturing delivers unbeatable performance consistency and reliability
• Easy to install and clean
• Extreme temperature and chemical compatibility

Analysis Note

Gravimetric Extractables: after 24 hours in water at controlled room temperature

Other Notes

These products are manufactured in a facility which adheres to Good Manufacturing Practices.

Legal Information

BIOMAX is a registered trademark of Merck KGaA, Darmstadt, Germany

Pellicon is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Skladovací třída: 12 - Non Combustible Liquids
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable