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MABC97

Anti-S1PR4/EDG6 Antibody, clone 16B9.1

clone 16B9.1, from mouse

Synonyma:

Sphingosine 1-phosphate receptor 4, S1P receptor 4, S1P4, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor Edg-6, S1P receptor Edg-6

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O této položce

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
16B9.1, monoclonal
Application:
IHC, WB
Citations:
2
Technický servis
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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

16B9.1, monoclonal

species reactivity

rat, human

technique(s)

immunohistochemistry: suitable, western blot: suitable

isotype

IgMκ

NCBI accession no.

NP_003766

UniProt accession no.

O95977

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... S1PR4(8698)

General description

Sphingosine 1-phosphate receptor 4 (S1PR4), otherwise known as EDG6, is present, in varying expression levels, in the adult lymph node, bone marrow, and thymus, as well as fetal liver, lung, and thymus. It is activated by the lysosphingolipid sphingosine 1-phosphate, and is coupled to Gi and G12/13 G proteins and via their various effector molecules, SIP4 regulates cell proliferation, differentiation, motility, and migration.
~42 kDa observed

Immunogen

GST-tagged recombinant protein corresponding to human S1PR4/EDG6.

Application

Detect S1PR4/EDG6 using this Anti-S1PR4/EDG6 Antibody, clone 16B9.1 validated for use in Western Blotting & IHC.
Immunohistochemistry Analysis: A 1:300 dilution from a representative lot detected S1PR4/EDG6 in human red bone marrow and human tonsil tissues.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot Analysis in rat spleen tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected S1PR4/EDG6 in 10 µg of rat spleen tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Skladovací třída

12 - Non Combustible Liquids

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Qun Zhu et al.
The FEBS journal, 281(12), 2861-2870 (2014-05-07)
It has been reported that the effect of inflammatory cytokines on β-cell destruction in type 1 diabetes is concentration-dependent. However, the underlying mechanisms remain unclear. In the present study, we found that a high concentration of cytokines promoted apoptosis in
Xiao-Jing Sun et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 32(8), 1313-1322 (2017-02-17)
C5a plays a crucial role in anti-neutrophil cytoplasmic antibody (ANCA)-mediated neutrophil recruitment and activation. Our previous studies found that the interaction between sphingosine-1-phosphate (S1P) and C5a plays an important role in the ANCA-mediated activation of neutrophils. In the current study

Globální číslo obchodní položky

Skladová položkaGTIN
MABC9704053252648366