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Merck

MABC567

Anti-Somatoliberin/GHRH Antibody, clone 1B4.2

clone 1B4.2, from mouse

Synonyma:

Somatoliberin, Growth hormone-releasing factor, GRF, Growth hormone-releasing hormone, GHRH, Somatocrinin, Somatorelin, Sermorelin, Somatoliberin/GHRH

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O této položce

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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Název produktu

Anti-Somatoliberin/GHRH Antibody, clone 1B4.2, clone 1B4.2, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1B4.2, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_001171660

UniProt accession no.

P01286

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Analysis Note

Evaluated by Western Blotting in human lung tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Somatoliberin/GHRH in 10 µg of human lung tissue lysate.

Application

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Somatoliberin/GHRH in human cerebral cortex tissue.
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
This Anti-Somatoliberin Antibody, clone 1B4.2 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of GHRH .

Biochem/physiol Actions

Clone 1B4.2 is expected to detect prepro-, pro-, and mature somatoliberin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The human GHRH (also known as GHRF) gene (Gene ID 2691) encodes the 108 aa Somatoliberin preproprotein (UniProt P01286; also known as GHRH, GRF, Growth hormone-releasing factor, Growth hormone-releasing hormone, INN: Sermorelin, Sermorelin, Somatocrinin, Somatorelin). Post-translatioinal removal of the signal peptide (aa 1-20) and the two propeptide sequences (aa 21-31 and aa 76-108) releases the 44 aa mature Somatoliberin (aa 32-75) that functions as a ligand to stimulate growth hormone (GH) release from the pituitary. Variant GHRH receptors are found in several types of tumors. Antagonists against such receptors are reported to inhibit tumors growth. Defects in GHRH gene cause dwarfism and hypersecretion of somatoliberin is linked to gigantism.
~12 kDa observed. Preprosomatoliberin (12.4 kDa calculated); Prosomatoliberin (10.9 kDa calculated); Mature somatoliberin (10.4 kDa calculated). Uncharacterized band(s) may appear in some lysates.

Immunogen

Epitope: Mature somatoliberin
KLH-conjugated linear peptide corresponding to mature human somatoliberin sequence.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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Skladovací třída

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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