ABS85
Anti-CPT2 Antibody
serum, from rabbit
Synonyma:
Carnitine O-palmitoyltransferase 2, mitochondrial, Carnitine palmitoyltransferase II, CPT II
Přihlásitk zobrazení cen stanovených pro organizaci a smluvních cen
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Doporučené produkty
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
species reactivity (predicted by homology)
human (immunogen homology)
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... CPT2(1376)
General description
Carnitine palmitoyltransferase II (CPT2, or CPT II) belongs to the carnitine/choline acetyltransferase family. It is a ubiquitous protein found in the inner membrane of the mitochondria and plays an essential role in fatty acid β-oxidation. CPT2 is part of the system involving CPT1 and carnitine/acylcarnitine translocase (CACT), that facilitate the transport of long chain fatty acids into the mitochondrial matrix. CPT2 plays the role of restoring these molecules to original esterified forms suitable for β-oxidation, after they arrive in the matrix. Defects in CPT2 has varying outcomes: in adults, it results in episodes of rhabdomyolysis (breakdown of muscle fibers which circulate in the bloodstream), after prolonged and vigorous exercise; and in infants, CPT2 deficiency induces hypoketotic hypoglycemia and eventual cardiac damage.
Immunogen
KLH-conjugated linear peptide corresponding to human CPT2.
Application
Anti-CPT2 detects levels of CPT2 proteins & has been published & validated for use in WB.
Quality
Evaluated by Western Blot in rat liver mitochondria tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected CPT2 on 10 µg of rat liver mitochondria tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected CPT2 on 10 µg of rat liver mitochondria tissue lysate.
Target description
~68 kDa observed (cleaved form). Uniprot gives a calculated weight of 74 kDa; however, CPT2 has been observed at ~68 kDa (Faye, A, et al. (2007). The Journal of Biological Chemistry. 282(37):26908–26916.). Uncharacterized bands appear at ~55, 58, 72, and 100 kDa in some lysates.
Analysis Note
Control
Rat liver mitochondria tissue lysate
Rat liver mitochondria tissue lysate
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
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Andrea S Pereyra et al.
The Journal of biological chemistry, 292(45), 18443-18456 (2017-09-17)
Cardiac hypertrophy is closely linked to impaired fatty acid oxidation, but the molecular basis of this link is unclear. Here, we investigated the loss of an obligate enzyme in mitochondrial long-chain fatty acid oxidation, carnitine palmitoyltransferase 2 (CPT2), on muscle
Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation.
Pereyra, et al.
Molecular Metabolism, 59, 101456-101456 (2022)
Michael L Blackburn et al.
American journal of physiology. Endocrinology and metabolism, 319(2), E265-E275 (2020-05-28)
Saturated fatty acids (SFAs) are implicated in muscle inflammation/cell stress and insulin resistance, but the catalog of factors involved is incomplete. SFA derivatives that accumulate with mismatched FA availability and FA oxidation (FAO) are likely involved, and evidence has emerged
Shahil H Patel et al.
International journal of molecular sciences, 23(24) (2022-12-24)
Smoking-derived nicotine (N) and oral contraceptive (OC) synergistically exacerbate ischemic brain damage in females, and the underlying mechanisms remain elusive. In a previous study, we showed that N + OC exposure altered brain glucose metabolism in females. Since lipid metabolism
Andrea S Pereyra et al.
Cell reports, 33(6), 108374-108374 (2020-11-12)
To assess the effects of acylcarnitine accumulation on muscle insulin sensitivity, a model of muscle acylcarnitine accumulation was generated by deleting carnitine palmitoyltransferase 2 (CPT2) specifically from skeletal muscle (Cpt2Sk-/- mice). CPT2 is an irreplaceable enzyme for mitochondrial long-chain fatty
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