645900

Triptolide

from Tripterygium wilfordii, ≥95% (HPLC), DEVD-cleaving caspases activator, solid

• Synonyma: Triptolide, Tripterygium wilfordii, PG490
• Empirický vzorec (Hillův zápis): C₂₀H₂₄O₆
• Číslo CAS: 38748-32-2
• Molekulová hmotnost: 360.40
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00210565
• Assay: ≥95% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Vlastnosti

• Název produktu: Triptolide, Tripterygium wilfordii, A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.
• Quality Level: 100
• description: RTECS - YK7751000
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 20 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O1[C@@]32[C@]5(O[C@H]5C[C@@H]6[C@@]3(CCC7=C6COC7=O)C)[C@@H]([C@]4(O[C@H]4[C@@H]21)C(C)C)O
• InChI: 1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
• InChI key: DFBIRQPKNDILPW-CIVMWXNOSA-N

Popis

General description

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Activate DEVD-cleaving caspases

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Other Notes

Zhao, Q., et al. 2005. J. Biol. Chem.280, 8101.
Shepherd, E., et al. 2004. J. Biol. Chem.279, 54023.
Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
Yang, Y., et al. 1998. Immunopharmacology40, 139.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Bezpečnostní informace

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H330,H361f
• pcodes: P202 - P260 - P264 - P271 - P280 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2
• Skladovací třída: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable