575310

T0901317

≥98% (HPLC), liver X receptor agonist, solid

• Synonyma: T0901317, TO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide
• Empirický vzorec (Hillův zápis): C₁₇H₁₂F₉NO₃S
• Číslo CAS: 293754-55-9
• Molekulová hmotnost: 481.33
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD03412028
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Vlastnosti

• Název produktu: T0901317, A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ of 20 nM for LXRα).
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: light beige
• solubility: DMSO: 50 mg/mL, ethanol: 50 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: FC(F)(F)CN([S](=O)(=O)c2ccccc2)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
• InChI: 1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
• InChI key: SGIWFELWJPNFDH-UHFFFAOYSA-N

Popis

General description

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ of 20 nM for LXR_α). Reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride in mice. Also reduces the development of atherosclerosis in LDL receptor-deficient mice and lowers plasma glucose in diabetic rodents.

Biochem/physiol Actions

Cell permeable: yes

EC50 = 20 nM for LXRα

Primary Target
Liver X receptor (LXRα)

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Terasaka, N., et al. 2003. FEBS Lett.536, 6.
Cao, G., et al. 2002. J. Biol. Chem.278, 1131.
Field, F.J., et al. 2002. Biochem. J.368, 855.
Fukumoto, H., et al. 2002. J. Biol. Chem.277, 48508.
DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA98, 1477.
Repa, J.J., et al. 2000. Science289, 1524.
Schultz, J.R., et al. 2000. Genes Dev.14, 2831.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable