370677

Guanosine 3′,5′-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt

A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II.

• Synonyma: Guanosine 3′,5′-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt, Rp-8- pCPT-cGMPS, TEA, PKG Inhibitor III
• Empirický vzorec (Hillův zápis): C₁₆H₁₅ClN₅O₆PS₂ · xC₆H₁₅N
• Molekulová hmotnost: 503.88 (free acid basis)
• NACRES: NA.77
• UNSPSC Code: 41106305
• Assay: ≥99% (HPLC)
• Form: lyophilized
• Quality level: 100
• Storage condition: OK to freeze, desiccated (hygroscopic)

Vlastnosti

• Quality Level: 100
• assay: ≥99% (HPLC)
• form: lyophilized
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• solubility: water: 0.5 mg/mL, DMSO: soluble
• shipped in: ambient
• storage temp.: −20°C

Popis

General description

A potent, cell-permeable inhibitor of protein kinase G Iα, Iβ, and type II. A combination of the protein kinase inhibitor Rp-cGMPS and the widely used cGMP analog, 8-pCPT-cGMP. Significantly more lipophilic and membrane-permeant than Rp-cGMPS and Rp-8-Br-cGMPS. Resistant to hydrolysis by mammalian cyclic nucleotide dependent phosphodiesterases. Note: 1 µmol = 0.61 mg.

A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II. Significantly more lipophilic and membrane-permeable than Rp-cGMPS or Rp-8-Br-cGMPS (Cat. No. 370674). Note: 1 µmol = 0.61 mg.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKG1α

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Abd Alla, S., et al. 1996. Eur. J. Biochem.241, 498.
Lee, S.J., et al. 1996. Dev. Biol.180, 324.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol.60, 94.
Willmott, N., et al. 1996. J. Biol. Chem.271, 3699.
Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.

Legal Information

Sold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable