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368044

Granzyme A, Human, Recombinant, E. coli

Name: Granzyme A, Human, Recombinant, <i>E. coli</i>
Brand: MM

Granzyme A, Human, Recombinant, E. coli, is a trypsin-like serine protease secreted by cytotoxic T cells and natural killer cells. Induces cell death through caspase-independent mechanism.

Synonyma:

GzmA

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O této položce

Číslo EC:

3.4.21.78 (BRENDA, IUBMB)

NACRES:

NA.77

UNSPSC Code:

12352202

Form:

liquid

Recombinant:

expressed in E. coli

Technický servis

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Vlastnosti

recombinant

expressed in E. coli

Quality Level

100

form

liquid

specific activity

≥100 units/μg protein

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

shipped in

wet ice

storage temp.

−70°C

Popis

General description

Recombinant, human granzyme A expressed in E. coli. Granzyme A is a trypsin-like serine protease found in the cytotoxic granules and secreted by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme A is a pro-apoptotic enzyme that induces cell death through a caspase-independent mechanism. Granzyme A-induced apoptosis results in single-stranded DNA nicking, nuclear fragmentation, chromatin condensation, loss of mitochondrial potential, and membrane blebbing. Granzyme A is also known to bind to and cleave nucleolin, activate the thrombin receptor on neuronal cells and astrocytes, cleave and activate interleukin-1β, and cleave putative HLA-associated protein II (PHAP II). Recombinant human Granzyme A expressed in E. coli.

Physical form

In 520 mM NaCl, 50 mM MES, 10% glycerol, pH 6.0.

Other Notes

Fan, Z., et al. 2002. Mol. Cell. Biol.22, 2810.
Russell, J.H., and Ley, T. J. 2002. Annu. Rev. Immunol.20, 323.
Beresford, P.J., et al. 2001. J. Biol. Chem.276, 43285.
Simon, M.M., and Kramer, M.D. 1994. Methods Enzymol.244, 68.

One unit is defined as the amount of enzyme that hydrolyzes 1 nmol Z-Lys-SBzl per min 25°C, pH 8.0.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Skladovací třída

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c