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O této položce
Form:
solution
Technický servis
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Fibronectin, Bovine Plasma, solution, Extracellular matrix (ECM) glycoprotein, Suitable for cell adhesion, growth, migration, and differentiation.
Quality Level
description
Merck USA index - 14, 4075
form
solution
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
shipped in
dry ice
storage temp.
−20°C
General description
Fibronectin is an extracellular matrix (ECM) glycoprotein. It is expressed in various cell types. Fibronectin exists as a dimer and is made up of identical subunits which are linked covalently via a disulfide bond at their C-termini.
Application
Fibronectin, Bovine Plasma has been used as an extracellular matrix (ECM) substrate to coat dishes or polyacrylamide hydrogels for adhering:
- human melanoma cancer cells
- human breast epithelial cells
- mouse embryonic fibroblasts
Biochem/physiol Actions
Fibronectin plays a role in cell adhesion, growth, migration, and differentiation. It binds to several molecules such as integrins, heparin, fibrin, and collagen.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In 150 mM NaCl, 20 mM sodium phosphate buffer, pH 7.3.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Analysis Note
single band by SDS-PAGE
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Skladovací třída
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Osvědčení o analýze (COA)
Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.
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Související obsah
Purva Singh et al.
Annual review of cell and developmental biology, 26, 397-419 (2010-08-10)
In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are induced to self-associate and to interact with other ECM proteins to form fibrillar networks. Matrix assembly is usually initiated by ECM glycoproteins binding to cell surface receptors, such
Jordi Pijuan et al.
Frontiers in cell and developmental biology, 7, 107-107 (2019-07-02)
Cell migration is a key procedure involved in many biological processes including embryological development, tissue formation, immune defense or inflammation, and cancer progression. How physical, chemical, and molecular aspects can affect cell motility is a challenge to understand migratory cells
Guillaume Jacquemet et al.
The Journal of cell biology, 216(10), 3387-3403 (2017-08-03)
Defective filopodia formation is linked to pathologies such as cancer, wherein actively protruding filopodia, at the invasive front, accompany cancer cell dissemination. Despite wide biological significance, delineating filopodia function in complex systems remains challenging and is particularly hindered by lack
Globální číslo obchodní položky
| Skladová položka | GTIN |
|---|---|
| 341631-5MG | 04055977194906 |
| 341631-1MG | 04055977194883 |