324385

Doxycycline, Hyclate

A commonly-used broad-spectrum antibiotic.

• Synonyma: Doxycycline, Hyclate, α-6-Deoxy-5-hydroxytetracycline, Vibramycin, Hyclate
• Empirický vzorec (Hillův zápis): C₂₂H₂₄N₂O₈ · 0.5H₂O · 0.5C₂H₆O · xHCl
• Číslo CAS: 24390-14-5
• Molekulová hmotnost: 476.48 (free base basis)
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD07357237

Vlastnosti

• Název produktu: Doxycycline, Hyclate, A commonly-used broad-spectrum antibiotic.
• InChI: 1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;3H,2H2,1H3;2*1H;1H2/b2*21-13+;;;;/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1
• InChI key: QDDHZFKCHWYXJF-PCLMCNLLSA-N
• assay: ≥98% (HPLC)
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: yellow to yellow-green
• solubility: water: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• Quality Level: 100

Popis

Biochem/physiol Actions

Primary Target
MMP-8

Product does not compete with ATP.

Reversible: no

Cell permeable: no

Target IC₅₀: 30 µM against MMP-8 (neutrophil collagenase); 25 µM inhibiting collagen synthesis by bovine articular chondrocytes cultured in alginate

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

General description

A commonly used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC₅₀ = 30 µM) relative to MMP-1 (collagenase-1; IC₅₀ = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC₅₀ = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.

A commonly-used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC₅₀ = 30 µM) relative to MMP-1 (interstitial collagenase; IC₅₀ = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC₅₀ = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.

Other Notes

D’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci.732, 112.
Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother.36, 227.

Preparation Note

Follwing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335,H361fd,H412
• pcodes: P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable