317639

Dipeptidylpeptidase IV, His•Tag^®, Human, Recombinant, S. frugiperda

DPPIV is involved in many cellular processes such as activation of cytokines, differentiation, and cell-matrix interactions. Inhibition of DPPIV has been reported to be an effective treatment for type II diabetes.

• Číslo EC: 3.4.14.5 (BRENDA, IUBMB)
• NACRES: NA.54
• UNSPSC Code: 12352202

Vlastnosti

• Název produktu: Dipeptidylpeptidase IV, His•Tag^®, Human, Recombinant, S. frugiperda, DPPIV is involved in many cellular processes such as activation of cytokines, differentiation, and cell-matrix interactions. Inhibition of DPPIV has been reported to be an effective treatment for type II diabetes.
• assay: ≥90% (SDS-PAGE)
• form: liquid
• specific activity: ≥8 units/mg protein
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles
• shipped in: wet ice
• storage temp.: −70°C
• Quality Level: 100

Popis

Disclaimer

Toxicity: Standard Handling (A)

General description

DPPIV is involved in many cellular processes such as activation of cytokines, differentiation, and cell-matrix interactions. Inhibition of DPPIV has been reported to be an effective treatment for type II diabetes.

Note: 1 mU = 1 milliunit.

Recombinant, human DPP IV fused at the N-terminus to a His•Tag sequence and expressed in S. frugiperda insect cells. A serine exopeptidase dimer composed of two identical subunits of 110-130 kDa. DPPIV is involved in many cellular processes such as activation of cytokines, differentiation, and cell-matrix interactions. Inhibition of DPPIV has been reported to be an effective treatment for type II diabetes. Note: 1 mU = 1 milliunit.

Other Notes

One unit is defined as the amount of enzyme that will hydrolyze 1 µmole H-Gly-Pro-AMC per min at 37°C, pH 8.0.

Pospisilik, JA, et al. 2003. Diabetes52, 741.
Dobers, J., et al. 2002. Protein Expr. Purif.25, 527.
Marguet, D., et al. 2000. Proc. Natl. Acad. Sci.97, 6874.
Misumi, Y., et al. 1992. Biochim. Biophys. Acta1131, 333.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 20 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% NaN₃, pH 8.0.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• wgk: WGK 1
• flash_point_f: does not flash
• flash_point_c: does not flash