317505

1,2-Dioctanoyl-sn-glycerol

Cell-permeable activator of protein kinase C (PKC).

• Synonyma: 1,2-Dioctanoyl-sn-glycerol, DOG, PKC Activator IV
• Empirický vzorec (Hillův zápis): C₁₉H₃₆O₅
• Číslo CAS: 60514-48-9
• Molekulová hmotnost: 344.49
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• form: oil
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: clear colorless
• solubility: chloroform: soluble; ethyl acetate: soluble
• shipped in: wet ice
• storage temp.: −70°C
• InChI: 1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1
• InChI key: ZQBULZYTDGUSSK-KRWDZBQOSA-N

Popis

General description

Cell-permeable activator of protein kinase C (PKC). Exhibits lower affinity for PKC_α than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.

Cell-permeable activator of protein kinase C; however, it has lower affinity for PKCa than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Protein kinase C

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Analysis Note

Single spot by TLC

Other Notes

Ferro, T.J., et al. 1993. Am. J. Physiol. 264, L7.
MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.
Davis, R.J. 1985. J. Biol. Chem.260, 1562.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable