317505

1,2-Dioctanoyl-sn-glycerol

Cell-permeable activator of protein kinase C (PKC).

• Synonyma: 1,2-Dioctanoyl-sn-glycerol, DOG, PKC Activator IV
• Empirický vzorec (Hillův zápis): C₁₉H₃₆O₅
• Číslo CAS: 60514-48-9
• Molekulová hmotnost: 344.49
• MDL number: MFCD00036835
• UNSPSC Code: 12352200
• NACRES: NA.77
• Form: oil
• Storage condition: OK to freeze

Vlastnosti

• Quality Segment: 100
• description: RTECS - RH0764500
• form: oil
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: clear colorless
• solubility: chloroform: soluble, ethyl acetate: soluble
• shipped in: wet ice
• storage temp.: −70°C
• SMILES string: O([C@H](COC(=O)CCCCCCC)CO)C(=O)CCCCCCC
• InChI: 1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1
• InChI key: ZQBULZYTDGUSSK-KRWDZBQOSA-N

Popis

General description

Cell-permeable activator of protein kinase C (PKC). Exhibits lower affinity for PKC_α than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Protein kinase C

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Unstable in solution; reconstitute just prior to use.

Analysis Note

Single spot by TLC

Other Notes

Ferro, T.J., et al. 1993. Am. J. Physiol. 264, L7.
MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.
Davis, R.J. 1985. J. Biol. Chem.260, 1562.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Bezpečnostní informace

• Skladovací třída: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable