231085

Cilostamide

A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 70 nM).

• Synonyma: Cilostamide, N-Cyclohexyl-N-methyl-4-(1,2-dihydro-2-oxo-6-quinolyloxy)butyramide, OPC 3689
• Empirický vzorec (Hillův zápis): C₂₀H₂₆N₂O₃
• Číslo CAS: 68550-75-4
• Molekulová hmotnost: 342.43
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00673958
• Assay: ≥98% (TLC)
• Form: solid
• Storage condition: OK to freeze

Vlastnosti

• Quality Segment: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [nH]1c2c(cc[c]1=O)cc(cc2)OCCCC(=O)N(C3CCCCC3)C
• InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
• InChI key: UIAYVIIHMORPSJ-UHFFFAOYSA-N

Popis

General description

A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 70 nM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PDE 3

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 70 nM against PDE III

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Verghese, M.W., et al. 1995. J. Pharmacol. Exp. Ther. 272, 1313.
Christensen, S.B., and Trophy, T.J. 1994. Ann. Rep. Med. Chem. 29, 185.
Tang, K.M., et al. 1994. Eur. J. Pharmacol. 268, 105.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable