220467

2-Chloro-2′-deoxyadenosine

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity.

• Synonyma: 2-Chloro-2′-deoxyadenosine, 2CdA, Cladribine
• Empirický vzorec (Hillův zápis): C₁₀H₁₂ClN₅O₃
• Číslo CAS: 4291-63-8
• Molekulová hmotnost: 285.69
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00153939

Vlastnosti

• Název produktu: 2-Chloro-2′-deoxyadenosine, A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity.
• SMILES string: Clc1nc2[n](cnc2c(n1)N)[C@@H]3O[C@@H]([C@H](C3)O)CO
• InChI: 1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
• InChI key: PTOAARAWEBMLNO-KVQBGUIXSA-N
• description: Merck USA index - 14, 2337
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• Quality Level: 100

Popis

Biochem/physiol Actions

Cell permeable: no

Primary Target
Antileukemic and immunosuppressive activity

Product does not compete with ATP.

Reversible: no

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

General description

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.

Other Notes

Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H341,H361fd,H372
• pcodes: P202 - P260 - P264 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable