189404

Aurora Kinase Inhibitor II

The Aurora Kinase Inhibitor II, also referenced under CAS 331770-21-9, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyma: Aurora Kinase Inhibitor II, 4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline, Aurora Kinase Inhibitor II
• Empirický vzorec (Hillův zápis): C₂₃H₂₀N₄O₃
• Číslo CAS: 331770-21-9
• Molekulová hmotnost: 400.43
• UNSPSC Code: 12352200

Vlastnosti

• Název produktu: Aurora Kinase Inhibitor II, The Aurora Kinase Inhibitor II, also referenced under CAS 331770-21-9, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• InChI key: IMYVCWQAHSYYOO-UHFFFAOYSA-N
• InChI: 1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-8-10-17(11-9-16)27-23(28)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26)
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• Quality Level: 100

Popis

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Aurora Kinase

Product competes with ATP.

Reversible: no

Target IC₅₀: 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable anilinoquinazoline compound that acts as a potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC₅₀ = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.

A cell-permeable, potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC₅₀ = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.

Other Notes

Heron, N.M., et al. 2006. Bioorg. Med. Chem. Lett.16, 1320.
Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem.5, 807.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable