189291

Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem

A cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC₅₀ = 7.5 nM in rat liver microsomes).

• Synonyma: Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem, (3 R,5 R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,, (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,
• Lineární vzorec: [(C₃₃H₃₄FN₂O₅)2Ca · 3H₂O]_1/2
• Číslo CAS: 134523-03-8
• UNSPSC Code: 12352200

Vlastnosti

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic), protect from light
• color: white
• solubility: methanol: 10 mg/mL, clear, colorless, DMSO: 100 mg/mL, clear, colorless, ethanol: 2 mg/mL, clear, colorless, water: insoluble
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/2C33H35FN2O5.Ca/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);/q;;+2/p-2/t2*26-,27-;/m11./s1
• InChI key: FQCKMBLVYCEXJB-MNSAWQCASA-L

Popis

General description

A cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC₅₀ = 7.5 nM in rat liver microsomes). Reduces cholesterol synthesis and increases the expression LDL receptors in hepatocytes. Exhibits anti-inflammatory and anti-oxidant properties. Acts as a hypotensive agent that acts by enhancing flow mediated dilation. Shown to overcome carboplatin resistance in non-small-cell lung carcinomas possibly by suppressing Akt activity and upregulating TIMP-1.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
Tycinska, A.M., et al. 2011. Arch. Med. Sci.7, 955.
Law, M.R., et al. 2003. BMJ326, 1423.

Youssef, S., et al. 2002. Nature420, 78.
Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol.18, 1906.

Bustos, C., et al. 1998. J. Am. Coll. Cardiol.32, 2057.
Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta1123, 133.
Roth, B.D., et al. 1991. J. Med. Chem.34, 463.
Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun.170, 726.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Bezpečnostní informace

• Skladovací třída: 10-13 - German Storage Class 10 to 13