149101-M

1-Aminocyclopropanecarboxylic acid

≥98% (TLC), crystalline solid, NMDA agonist, Calbiochem

• Synonyma: 1-Aminocyclopropane-1-carboxylic Acid, ACPC
• Empirický vzorec (Hillův zápis): C₄H₇NO₂
• Číslo CAS: 22059-21-8
• Molekulová hmotnost: 101.10
• UNSPSC Code: 12352106
• NACRES: NA.77
• MDL number: MFCD00009944
• Assay: ≥98% (TLC)
• Form: crystalline solid
• Quality level: 100
• Storage condition: OK to freeze

Vlastnosti

• Název produktu: 1-Aminocyclopropane-1-carboxylic Acid, An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.
• Quality Level: 100
• description: RTECS - GZ1110000
• assay: ≥98% (TLC)
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• solubility: water: 40 mg/mL
• storage temp.: 10-30°C
• SMILES string: [N+H3]C1(CC1)C(=O)[O-]
• InChI: 1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7)
• InChI key: PAJPWUMXBYXFCZ-UHFFFAOYSA-N

Popis

General description

A potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks ³H-glycine binding to rat forebrain membranes (IC₅₀ = 38 nM).

An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks ³H-glycine binding to rat forebrain membrane (IC₅₀ = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC₅₀ = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.

Biochem/physiol Actions

Primary Target
Glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex

Target IC₅₀: 38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

May require heating and sonication to achieve complete solubilization.

Other Notes

Viu, E., et al. 1998. J. Pharm. Exp. Ther.285, 527.
Zapata, A., et al. 1996. NeuroReport7, 397.
Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
Rottmann, W.H., et al. 1991. J. Mol. Biol.222, 937.
Marvizon, J.C., et al. 1989. J. Neurochem.52, 992.
Nadler, V., et al. 1988. Eur. J. Pharmacol.157, 115.
Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA76, 170.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable