129741
α-Amanitin, Amanita sp.
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≥90% (by absorbance)
form
lyophilized solid
color
white
solubility
H2O: 10 mg/mL, methanol: soluble
General description
α-Amanitin, Amanita sp. is a toxic bicyclic octapeptide isolated from mushrooms. A potent & specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes.
Toxic bicyclic octapeptide isolated from mushrooms. Acts as a potent and specific inhibitor of RNA polymerase II and messenger RNA synthesis in higher eukaryotes, including animals and plants.
Biochem/physiol Actions
RNA polymerase 2
Preparation Note
Reconstitute to a concentration ≥1 mM
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral - STOT RE 2
target_organs
Kidney,Blood,Liver,Gastrointestinal tract,Respiratory Tract,Central nervous system
Skladovací třída
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
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Související obsah
A Tamin et al.
Virology, 182(1), 393-396 (1991-05-01)
The locus responsible for encoding resistance to alpha-amanitin was previously mapped to the vaccinia virus (VV) HindIII N fragment by using cloned wild-type VV DNA fragments to rescue the ability of an alpha-amanitin-resistant/temperature-sensitive VV mutant (alpha rts7) to replicate under
C Scheurlen et al.
Zeitschrift fur Gastroenterologie, 32(7), 399-404 (1994-07-01)
Alpha-amanitin, the main toxin of the death cap fungus (Amanita phalloides) is one of the most dangerous natural poison. This toxin damages eukaryotic cells by inhibiting their transcription. Lesions are seen in cells with rapid protein synthesis, particular in liver
P M Kastrop et al.
Molecular reproduction and development, 28(3), 249-254 (1991-03-01)
Bovine cumulus oocyte complexes were cultured for various periods and either denuded and orcein stained or radiolabeled with 35S-methionine or 32P-orthophosphate. Specific inhibitors were added to the culture medium to investigate mRNA and protein synthesis requirements for both nuclear and