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04-921

Anti-GluR6/7 Antibody, clone NL9, rabbit monoclonal

culture supernatant, clone NL904, Upstate®

Synonyma:

Anti-EAA4, Anti-GLR6, Anti-GLUK6, Anti-GLUR6, Anti-GluK2, Anti-MRT6, Anti-NEDLAS

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O této položce

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
NL904, monoclonal
Application:
IP, WB
Citations:
37
Technický servis
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biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

NL904, monoclonal

species reactivity

mouse, rat, human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_021956

UniProt accession no.

Q13002

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GRIK2(2898)

General description

115 kDa

Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acids 894-908 (C-terminus) of rat GluR6. The immunizing sequence is identical in human.

Application

Anti-GluR6/7 Antibody, clone NL9 is an antibody against GluR6/7 for use in IP & WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors

Biochem/physiol Actions

Recognizes GluR6/7.

Physical form

None

Preparation Note

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Mouse brain tissue, rat brain microsomal preparation, human brain lysates
Routinely evaluated by immunoblot analysis.

Other Notes

Replaces: 05-921

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Skladovací třída

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Související obsah

Pathways and Biomarkers of Glutamatergic Synapse Flyer

Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.

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