Přejít k obsahu
Merck

03-309

Magna ChIRP® TERC lncRNA Probe Set

Přihlásit pro zobrazení organizačních a smluvních cen.

Vybrat velikost

O této položce

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Hlavní dokumenty

Zobrazit celou dokumentaci
Technický servis
Potřebujete pomoc? Náš tým zkušených odborníků je vám k dispozici.
Dovolte nám, abychom vám pomohli
Technický servis
Potřebujete pomoc? Náš tým zkušených odborníků je vám k dispozici.
Dovolte nám, abychom vám pomohli

Quality Level

100

technique(s)

DNA sequencing: suitable, nucleic acid detection: suitable

suitability

suitable for determination of protein concentration

General description

ChIRP (Chromatin Isolation by RNA Purification), allows recovery of specific segments of DNA and proteins using chromatin associated RNA as a target for biotinylated antisense probes. The Magna ChIRP TERC lncRNA Probe Set contains 19 predesigned 20-mer DNA oligonucleotides tiled along and complementary to the sequence of human lncRNA TERC. All probes are biotin-TEG-labeled at the 3-prime end. The oligonucleotides are split to two pools (even and odd) and are supplied ready-for-use by the ChIRP method. This probe set is fully compatible with the Maga ChIRP kits (cat. # 17-10494 and 17-10495).

Physical form

50 µM biotin-TEG-labeled 20-mer DNA oligonucleotides in containing 10 mM Tris-HCl, 1mM EDTA, pH 8.0

Preparation Note

Upon receipt store at -20°C. Avoid multiple freeze thaws. With proper storage and handling this product is stable for 6 months from the date of receipt.

Legal Information

MAGNA CHIRP is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Skladovací třída

12 - Non Combustible Liquids

wgk

nwg

Osvědčení o analýze (COA)

Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.

Již tento produkt vlastníte?

Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.

Navštívit knihovnu dokumentů

Související obsah

New Products - Antibodies, Small Molecule, Inhibitors

"Cancer research giving you mixed signals? Signaling molecules are deeply embedded in processes associated with cancer. The study of signaling pathways is nearly synonymous with cancer research. Elucidating the various cellular and molecular mechanisms of cancer requires high quality research tools that give you precise, reproducible data. At EMD Millipore, our scientists are dedicated to developing and delivering thoroughly tested and validated tools for life science research."

NPI Flyer- Epigenetics and Nuclear Function Feature

Historically chromatin was considered to contain only DNA, histones, non-histone proteins and transiently associated mRNAs. While this remains true, current data suggest that a variety of non-coding RNAs (e.g. long non-coding RNAs, enhancer RNAs and even miRNAs) also associate with chromatin and serve regulatory functions.

White Paper - The Message in the Marks: Deciphering Cancer Epigenetics

Cancer is a complex disease manifestation. At its core, it remains a disease of abnormal cellular proliferation and inappropriate gene expression. In the early days, carcinogenesis was viewed simply as resulting from a collection of genetic mutations that altered the gene expression of key oncogenic genes or tumor suppressor genes leading to uncontrolled growth and disease (Virani, S et al 2012). Today, however, research is showing that carcinogenesis results from the successive accumulation of heritable genetic and epigenetic changes. Moreover, the success in how we predict, treat and overcome cancer will likely involve not only understanding the consequences of direct genetic changes that can cause cancer, but also how the epigenetic and environmental changes cause cancer (Johnson C et al 2015; Waldmann T et al 2013). Epigenetics is the study of heritable gene expression as it relates to changes in DNA structure that are not tied to changes in DNA sequence but, instead, are tied to how the nucleic acid material is read or processed via the myriad of protein-protein, protein-nucleic acid, and nucleic acid-nucleic acid interactions that ultimately manifest themselves into a specific expression phenotype (Ngai SC et al 2012, Johnson C et al 2015). This review will discuss some of the principal aspects of epigenetic research and how they relate to our current understanding of carcinogenesis. Because epigenetics affects phenotype and changes in epigenetics are thought to be key to environmental adaptability and thus may in fact be reversed or manipulated, understanding the integration of experimental and epidemiologic science surrounding cancer and its many manifestations should lead to more effective cancer prognostics as well as treatments (Virani S et al 2012).

Náš tým vědeckých pracovníků má zkušenosti ve všech oblastech výzkumu, včetně přírodních věd, materiálových věd, chemické syntézy, chromatografie, analytiky a mnoha dalších..

Obraťte se na technický servis