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P38803

Sigma-Aldrich

Phthalhydrazide

ReagentPlus®, 99%

Synonyma:

2,3-Dihydro-1,4-phthalazinedione

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About This Item

Empirický vzorec (Hillův zápis):
C8H6N2O2
Číslo CAS:
1445-69-8
Molekulová hmotnost:
162.15
EC Number:
215-893-4
MDL number:
MFCD00006888
UNSPSC Code:
12352100
PubChem Substance ID:
24898463
NACRES:
NA.22

product line

ReagentPlus®

assay

99%

form

solid

mp

>300 °C (lit.)

SMILES string

O=C1NNC(=O)c2ccccc12

InChI

1S/C8H6N2O2/c11-7-5-3-1-2-4-6(5)8(12)10-9-7/h1-4H,(H,9,11)(H,10,12)

InChI key

KGLPWQKSKUVKMJ-UHFFFAOYSA-N

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Související kategorie

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Osvědčení o analýze (COA)

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4-Aminobenzoic hydrazide 95%

Sigma-Aldrich

A41909

4-Aminobenzoic hydrazide

Carbohydrazide 98%

Sigma-Aldrich

C11006

Carbohydrazide

Succinic dihydrazide 96%

Sigma-Aldrich

S5502

Succinic dihydrazide

Oxalyldihydrazide 98%

Sigma-Aldrich

131296

Oxalyldihydrazide

Hydrazine monohydrate N2H4 64-65 %, reagent grade, ≥97%

Sigma-Aldrich

207942

Hydrazine monohydrate

Luminol 97%

Sigma-Aldrich

123072

Luminol

Hydrazinium hydroxide (about 100% N₂H₅OH) for synthesis

Sigma-Aldrich

8.04608

Hydrazinium hydroxide

I H Hall et al.
The Journal of pharmacy and pharmacology, 41(6), 394-397 (1989-06-01)
The disposition of [14C]2,3-dihydrophthalazine-1,4-dione, a potent hypolipidaemic agent, has been determined after both intravenous and oral administration. Both the routes of administration afforded multi-exponential disposition with an estimated t1/2 of approximately 75 h. After oral administration, the drug was observed
J Schiller et al.
Free radical research, 30(1), 45-57 (1999-04-08)
The reactivity of 5-amino-2,3-dihydro-phthalazine-1,4-dione (luminol) and phthalic hydrazide with hydroxyl radicals was studied. HO*-radicals were generated by the Fenton reaction as well as by water radiolysis. Both luminol and phthalic hydrazide react with hydroxyl radicals under intense chemiluminescence (CL) emission.
I H Hall et al.
Biomedica biochimica acta, 47(4-5), 423-433 (1988-01-01)
2,3-Dihydrophthalazine-1,4-dione effectively lowers serum levels of cholesterol and triglycerides in Sprague Dawley rats after two weeks, after which the cholesterol levels continued to decline. The maximum serum lipid lowering effect on cholesterol or triglyceride levels was during the seventh and
I H Hall et al.
Anti-cancer drugs, 3(1), 55-62 (1992-02-01)
2,3-Dihydrophthalazine-1,4-dione derivatives demonstrated potent cytotoxicity against the growth of murine leukemia cells and human single cell suspension, i.e. Tmolt3 leukemia and HeLa-S3, as well as colon adenocarcinoma and KB nasopharynx. However, only select compounds demonstrated activity against bronchogenic lung, osteosarcoma
L Butner et al.
International journal of tissue reactions, 18(2-3), 47-55 (1996-01-01)
2,3-Dihydrophthalazine-1,4-diones were observed to be potent anti-inflammatory agents as well as capable of protecting against endotoxin shock in mice at 8 mg/kg i.p. These agents blocked both locally- and centrally-induced pain at 8 mg/kg i.p. In part they appear to

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