934372

MC-Val-Cit-PAB-PNP

≥95%

• Synonyma: L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N⁵-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
• Empirický vzorec (Hillův zápis): C₃₅H₄₃N₇O₁₁
• Číslo CAS: 159857-81-5
• Molekulová hmotnost: 737.76
• Beilstein/REAXYS Number: 10322169
• UNSPSC Code: 12352200
• PubChem Substance ID: 468592337
• NACRES: NA.22
• MDL number: MFCD22200431
• Assay: ≥95%
• Form: powder

Vlastnosti

• Quality Segment: 100
• assay: ≥95%
• form: powder
• reaction suitability: reagent type: cross-linking reagent
• storage temp.: 2-8°C
• SMILES string: [N+](=O)([O-])c1ccc(cc1)OC(=O)OCc2ccc(cc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCCN3C(=O)C=CC3=O)C(C)C)CCCNC(=O)N
• InChI key: HYSPJPGXSALJRR-DHIFEGFHSA-N

Popis

Application

This is a bifunctional cathepsin cleavable linker used in the construction of antibody drug conjugates (ADC).

Features and Benefits

The maleimide functionality can be used for bioconjugation to thiols in monoclonal antibodies while the activated carbonate esters can be used for construction of carbamate linkages with amine containing payloads.

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• Co se děje?: WGK 3
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable