930822

3-[1,3-Dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione

≥95.0%

• Synonyma: 2,6-Piperidinedione, 3-[1,3-dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2H-isoindol-2-yl]
• Empirický vzorec (Hillův zápis): C₁₈H₁₈N₂O₄
• Číslo CAS: 2138441-30-0
• Molekulová hmotnost: 326.35
• UNSPSC Code: 12352101
• NACRES: NA.21
• MDL number: MFCD32903469

Vlastnosti

• Quality Segment: 100
• assay: ≥95.0%
• form: powder
• technique(s): targeted protein degradation: suitable
• functional group: hydroxyl
• storage temp.: 2-8°C

Popis

Application

3-[1,3-Dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione is a functionalized cereblon (CRBN) ligand used in the development of lenalidomide-based protein degrader building blocks. Can be activated by many nucleophiles or form ether linkages through its terminal hydroxyl group. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules


Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG


Small-Molecule PROTACS: New Approaches to Protein Degradation


Targeted Protein Degradation: from Chemical Biology to Drug Discovery


Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^®

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• Co se děje?: WGK 3
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable