930717

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-piperidinyloxy) hydrochloride

≥95%

• Empirický vzorec (Hillův zápis): C₁₈H₁₉N₃O₅ · xHCl
• Číslo CAS: 2640388-58-3
• Molekulová hmotnost: 357.36 (free base basis)
• UNSPSC Code: 12352101
• NACRES: NA.22
• MDL number: MFCD34571034

Vlastnosti

• Quality Segment: 100
• assay: ≥95%
• form: powder
• technique(s): targeted protein degradation: suitable
• functional group: amine
• storage temp.: 2-8°C
• SMILES string: O=C1NC(C(CC1)N2C(C3=CC=C(C=C3C2=O)OC4CCNCC4)=O)=O
• InChI key: CDJLIKLSVQGZKT-UHFFFAOYSA-N

Popis

Application

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-piperidinyloxy) Hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library.


Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation


Protein Degrader Building Blocks

Other Notes

Targeted Protein Degradation by Small Molecules


Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG


Small-Molecule PROTACS: New Approaches to Protein Degradation


Targeted Protein Degradation: from Chemical Biology to Drug Discovery


Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Bezpečnostní informace

• Piktogramy: GHS08
• Výstražné slovo: Danger
• Kódy nebezpečí: H360D
• Bezpečnostní pokyny: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable