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V9889

Sigma-Aldrich

Valacyclovir hydrochloride hydrate

≥98% (HPLC), solid

Synonym(s):

2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester monohydrochloride, L-Valine, Valtrex

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About This Item

Empirical Formula (Hill Notation):
C13H20N6O4 · HCl · xH2O
CAS Number:
124832-27-5
Molecular Weight:
360.80 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329830241
NACRES:
NA.32

Quality Level

100

Assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: >20 mg/mL

antibiotic activity spectrum

viruses

Mode of action

DNA synthesis | interferes

storage temp.

room temp

SMILES string

O.Cl.CC(C)[C@H](N)C(=O)OCCOCn1cnc2C(=O)NC(N)=Nc12

InChI

1S/C13H20N6O4.ClH.H2O/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20;;/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20);1H;1H2/t8-;;/m0../s1

InChI key

KNOVZDRKHSHEQN-JZGIKJSDSA-N

Biochem/physiol Actions

Valacyclovir hydrochloride hydrate is potent inhibitor of viral DNA polymerase. It is a prodrug of acyclovir that is useful in viral, AIDS, and immune system regulation research.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S P Alexopoulos et al.
Current medicinal chemistry, 19(35), 5957-5963 (2012-09-12)
Human Cytomegalovirus is a commonly identified herpesvirus that establishes a state of latent infection in the majority of the population by adulthood. A coordinated immune response involving both the innate and adaptive immune system prevents active viral replication and disease.
Shin-ichi Sasaki et al.
The British journal of ophthalmology, 97(4), 498-503 (2013-01-31)
To determine the efficacy of a new helicase-primase inhibitor, ASP2151, for treating herpetic keratitis. Murine corneas were infected with herpes simplex virus type 1 (HSV-1). ASP2151 was administered orally or topically, and the severity of epithelial dendritic keratitis was determined.
Leigh Zerboni et al.
Journal of virology, 87(5), 2791-2802 (2012-12-28)
The tropism of herpes simplex virus (HSV-1) for human sensory neurons infected in vivo was examined using dorsal root ganglion (DRG) xenografts maintained in mice with severe combined immunodeficiency (SCID). In contrast to the HSV-1 lytic infectious cycle in vitro
Adnan H Siddiqui et al.
Neurology, 83(5), 441-449 (2014-07-01)
We report the results of the investigation of safety and efficacy of venous angioplasty in patients with multiple sclerosis (MS) with findings of extracranial venous anomalies, considered hallmarks of chronic cerebrospinal venous insufficiency (CCSVI), in a 2-phase study (ClinicalTrials.gov NCT01450072).
Mark Beswick et al.
Journal of virology, 87(2), 779-789 (2012-11-02)
Cytomegalovirus (CMV) infection leads to the development of adaptive and humoral immune responses that are among the largest for any pathogen, and intriguingly, the magnitude of the immune response increases with age, a phenomenon termed "memory inflation." Elevated CMV-specific immunity
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