SML1527

Acetato de abiraterona

≥98% (HPLC)

• Sinónimos: 17-(piridina-3-il)androsta-5,16-dien-3β-il acetato
• Fórmula empírica (notación de Hill): C₂₆H₃₃NO₂
• Número de CAS: 154229-18-2
• Peso molecular: 391.55
• Número MDL: MFCD00934213
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825944
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 5 mg/mL, clear
• temp. de almacenamiento: −20°C
• cadena SMILES: C[C@]12C(C[C@@H](OC(C)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CC=CN=C5
• InChI: 1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1
• Clave InChI: UVIQSJCZCSLXRZ-UBUQANBQSA-N
• Información sobre el gen: human ... CYP17A1(1586)

Descripción

Aplicación

Abiraterone acetate has been used to study its antitumor action in 3D micro-tumour platform.

Acciones bioquímicas o fisiológicas

Abiraterone acetate is a prodrug of abiraterone, which is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Abiraterone acetate is used for the treatment of metastatic castration-resistant prostate cancer. Abiraterone acetate possesses significant antitumor activity in post-docetaxel patients with CRPC (castration-resistant prostate cancer). It is highly essential for androgen biosynthesis in the testes, adrenal glands, and prostate tissue.

Información de seguridad

• Pictogramas: GHS08,GHS09
• Palabra de señalización: Danger
• Frases de peligro: H360F,H373,H410
• Consejos de prudencia: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Clasificaciones de peligro: Aquatic Chronic 1 - Repr. 1B - STOT RE 2
• Órganos de actuación: Endocrine system
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable