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SML0476

Sigma-Aldrich

Rabeprazole sodium

≥98% (HPLC)

Sinónimos:

2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole, Pariprazole

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About This Item

Fórmula empírica (notación de Hill):
C18H20N3O3S · Na
Número de CAS:
117976-90-6
Peso molecular:
381.42
UNSPSC Code:
12352200
PubChem Substance ID:
329825431
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL (clear solution)

shipped in

wet ice

storage temp.

−20°C

SMILES string

[Na+].COCCCOc1ccnc(CS(=O)c2nc3ccccc3[n-]2)c1C

InChI

1S/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18;/h3-4,6-9H,5,10-12H2,1-2H3;/q-1;+1

InChI key

KRCQSTCYZUOBHN-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495) , ATP4B(496)

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Application

Rabeprazole sodium has been used as a proton pump inhibitor (PPI) to study its effects on spontaneous uterine contractile activity in pregnant women.

Biochem/physiol Actions

Rabeprazole sodium is gastric proton pump inhibitor. It suppresses the production of acid in the stomach by inhibiting the gastric H+/K+ATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Rabeprazole sodium has been used clinically to treat acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevent gastroinetestinal bleeds associated with NSAID use.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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C Terranova et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 52, 125-131 (2013-11-13)
In this study we investigate in in vitro myometrial tissue samples of pregnant women: (a) the effects of proton pomp inhibitors (PPIs) (omeprazole, esomeprazole, pantoprazole, lansoprazole and rabeprazole) on spontaneous contractions; (b) the muscle-relaxant efficacy of the most active PPI
Leonhard X Heinz et al.
Nature, 581(7808), 316-322 (2020-05-21)
Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses1-3. Here we show that a previously uncharacterized protein encoded by CXorf21-a gene that is associated with systemic lupus erythematosus4,5-interacts with the endolysosomal transporter
Increased gap density predicts weakness of the epithelial barrier in vivo by confocal laser endomicroscopy in indomethacin-induced enteropathy.
Shi S, Wang H, Gao H, et al.
Digestive Diseases and Sciences, 59(7), 1398-1405 (2014)
Hyun Jeong Lee et al.
The Journal of infectious diseases, 208(7), 1123-1130 (2013-06-27)
Clarithromycin-resistant Helicobacter pylori is associated with point mutations in the 23S ribosomal RNA (rRNA) gene. A total of 1232 patients participated and were divided into 2 control groups and 1 case group. Patients in the APC control group, which consisted
Tarek A Ahmed et al.
Life sciences, 110(1), 35-43 (2014-07-06)
First; to develop rabeprazole (RP)-alginate core coated chitosan nanoparticles (NP) utilizing water in oil (W/O) nanoemulsion technique. Second; formulation of transdermal patches loaded RP-NP that avoid drug peroral acid sensitivity and first pass effect. The influence of six factors on

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