SML0142

Valsartan

≥98% (HPLC)

• Sinónimos: N-(1-Oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine
• Fórmula empírica (notación de Hill): C₂₄H₂₉N₅O₃
• Número de CAS: 137862-53-4
• Peso molecular: 435.52
• Número MDL: MFCD00865840
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825190
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• actividad óptica: [α]/D -55 to -70°, c = 1 in methanol
• condiciones de almacenamiento: desiccated
• color: white to tan
• solubilidad: DMSO: ≥20 mg/mL
• emisor: Novartis
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CCCCC(=O)N(Cc1ccc(cc1)-c2ccccc2-c3nnn[nH]3)[C@@H](C(C)C)C(O)=O
• InChI: 1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
• Clave InChI: ACWBQPMHZXGDFX-QFIPXVFZSA-N
• Información sobre el gen: human ... AGTR1(185)

Descripción

Aplicación

Mice were treated with valsartan to study the role of Ang II-dependent pathway in aldosterone-related effects.

Acciones bioquímicas o fisiológicas

Valsartan is an Angiotensin II type 1 (AT1) receptor antagonist and anti-hypertensive. Valsartan renders protection against heart attack and stroke resulting from abrupt increase in blood pressure. Valsartan reduces myocardial-infarction-related complications in heart attack survivors.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Warning
• Frases de peligro: H336,H361d
• Consejos de prudencia: P201 - P308 + P313
• Clasificaciones de peligro: Repr. 2 - STOT SE 3
• Órganos de actuación: Central nervous system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable