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Key Documents

SAB4502482

Sigma-Aldrich

Anti-PTGER3 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

EP3 subtype, PGE receptor, PGE2-R, Prostaglandin E2 receptor EP3 subtype, Prostanoid EP3 receptor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 43 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PTGER3(5733)

General description

The PTGER3 (prostaglandin E receptor 3) gene is mapped to human chromosome 1p31.1 and encodes a Gαi coupled receptor protein. It is predominantly localized to the brain in the neurons and activated glial cells. Anti-PTGER3 antibody detects endogenous levels of total PTGER3 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human PTGER3.

Immunogen Range: 16-65

Biochem/physiol Actions

Prostaglandin E receptor 3 (PTGER3) serves as a receptor for prostaglandin (PG) E1 and E2, to carry out a number of physiological processes. PTGER3 specifically functions to reduce adenylyl cyclase action. It is involved in the activation of the Ras signaling pathway.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Visite la Librería de documentos

Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury
Han, X, et al.
Journal of Cerebral Blood Flow and Metabolism, 36(6), 1059-1074 (2016)
The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE 2-and retaining PGE 1-mediated signaling in live cells
Akasaka H
Archives of Biochemistry and Biophysics, 616, 20-29 (2017)
Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells
Li C, et al.
Molecular Cancer Research (2017)
Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival.
Ragnarsson G
British Journal of Cancer, 79(9-10), 1468-1474 (1999)

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