S0441

SB-366791

≥98% (HPLC), powder

• Sinónimos: N-(3-Methoxyphenyl)-4-chlorocinnamide
• Fórmula empírica (notación de Hill): C₁₆H₁₄NO₂Cl
• Número de CAS: 472981-92-3
• Peso molecular: 287.74
• Número MDL: MFCD01033818
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278690
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 5 mg/mL, clear
• emisor: GlaxoSmithKline
• cadena SMILES: COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1
• InChI: 1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
• Clave InChI: RYAMDQKWNKKFHD-JXMROGBWSA-N
• Información sobre el gen: human ... TRPV1(7442)

Descripción

Aplicación

SB-366791 has been used as a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist:

• to infer the in vitro and in vivo pharmacology of (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (AMG 9810)
• to study its effects on sodium hydrogen sulfide (NaHS) or capsaicin-induced contractile activity
• to study the inhibitory potency of phoneutria toxin (PnTx3-5) (native and recombinant) on various responses mediated by transient receptor potential cation channel subfamily V member 1 (TRPV1)

Acciones bioquímicas o fisiológicas

SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.

Vanilloid receptor-1 (TRPV1) antagonist.

Características y beneficios

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)