This product is tested for solubility in methanol at 50 mg/mL and is also soluble in ethanol and DMSO. The stability in solution has not been determined. However, an identical product, 524488, notes that solutions are stable when stored in aliquots at -20°C for up to 1 month.
P7912
Phloretin
≥99% (HPLC), powder, GLUT inhibitor
Sinónimos:
β-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone, 2′,4′,6′-Trihydroxy-3-(4-hydroxyphenyl)propiophenone, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
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About This Item
Fórmula empírica (notación de Hill):
C15H14O5
Número de CAS:
Peso molecular:
274.27
Beilstein/REAXYS Number:
1887240
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
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Nombre del producto
Phloretin, ≥99%
Quality Level
assay
≥99%
form
powder
mp
~260 °C
storage temp.
2-8°C
SMILES string
Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
InChI
1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
InChI key
VGEREEWJJVICBM-UHFFFAOYSA-N
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General description
Major polyphenol found in apple; aglycone of phloridzin.
Phloretin a polar dye belongs to the class of dihydrochalcones.[1]
Application
Phloretin has been used:
- to study its effect on the 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) and 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-l-glucose (2-NBDLG) uptake[2]
- to incubate microvesicles in order to inhibit GLUT1 (glucose transporter 1)-mediated transport in radioactive ligand up-take assay[3]
- as a component of KRH buffer to stop glucose uptake by trophoblast cells in vitro[4]
Biochem/physiol Actions
Blocks L-type Ca2+ channels; activates Ca2+-activated K+ channels in amphibian myelinated nerve fibers. Monocarboxylate transporter inhibitor.
Phloretin is known to decrease interfacial dipole potential of lipid bilayer.[5] Phloretin possess antitumor action by preventing protein kinase C (PKC) activity and stimulating programmed cell death.[6] It is found to inhibit the transport functions of GLUTs (glucose transporter) and aquaporins.[2]
Reacts with vic-dicarbonyl compounds such as glyoxal and methylglyoxal, preventing cytotoxic conjugation with biological macromolecules.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Los clientes también vieron
Insulin-dependent, glucose transporter 1 mediated glucose uptake and tube formation in the human placental first trimester trophoblast cells
Basak S, et al.
Molecular and Cellular Biochemistry, 55(,
pages=), 94-99 (2018)
Modulation of lipid bilayer interfacial dipole potential by phloretin, RH421, and 6-ketocholestanol as probed by gramicidin channel conductance
Duffin RL, et al.
Langmuir, 19(4), 1439-1442 (2003)
Samer Al-Samir et al.
Journal of enzyme inhibition and medicinal chemistry, 36(1), 1602-1606 (2021-07-16)
We have studied the CO2 permeability of the erythrocyte membrane of the rat using a mass spectrometric method that employs 18 O-labelled CO2. The method yields, in addition, the intraerythrocytic carbonic anhydrase activity and the membrane HCO3- permeability. For normal rat
Uptake of a fluorescent L-glucose derivative 2-NBDLG into three-dimensionally accumulating insulinoma cells in a phloretin-sensitive manner
Sasaki A, et al.
Human Cell : Official Journal of Human Cell Research Society, 29(1), 37-45 (2016)
Placental glucose transporter (GLUT)-1 is down-regulated in preeclampsia
Luscher BP, et al.
Placenta, 55(,
pages=), 94-99 (2017)
Artículos
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
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この製品の溶解方法と溶解した後の保存方法と、保存可能期間をどうか教えてください。 Please let me know how to dissolve this product, how to store it, and how long it can be stored after dissolving.
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What is the solubility of Phloretin in DMSO?
1 answer-
Stock solutions of phloretin can be prepared in DMSO at 100 mM
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