P7265

Prostaglandin A₁

≥98% (HPLC), powder, NF-κB inhibitor

• Sinónimos: (13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA₁
• Fórmula empírica (notación de Hill): C₂₀H₃₂O₄
• Número de CAS: 14152-28-4
• Peso molecular: 336.47
• Beilstein/REAXYS Number: 2003401
• MDL number: MFCD00077858
• UNSPSC Code: 12352211
• PubChem Substance ID: 24898834
• NACRES: NA.77

Propiedades

• product name: Prostaglandin A₁, synthetic
• biological source: synthetic
• Quality Level: 200
• assay: ≥98%
• form: powder
• storage temp.: −20°C
• SMILES string: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1
• InChI: 1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
• InChI key: BGKHCLZFGPIKKU-LDDQNKHRSA-N

Descripción

Biochem/physiol Actions

Prostaglandin A1 (PGA1) is a cyclopentenone prostaglandin containing chemically reactive α,β-unsaturated carbonyl. This cyclooxygenase 2 (COX-2) metabolic product aids in regulating the development and progression of Alzheimer′s disease (AD). In addition, PGA1 also regulates various biological processes via Michael addition. It exhibits antiviral activity against avian influenza A viruses (IAV) by inducing cytoprotective heat shock response in infected cells and by inhibiting nuclear factor-κB (NF-κB) activity.

Información de seguridad

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H360F
• pcodes: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)