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Merck
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Key Documents

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N7382

Sigma-Aldrich

Nitrosomorpholine

Sinónimos:

NMOR

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About This Item

Fórmula empírica (notación de Hill):
C4H8N2O2
Número de CAS:
59-89-2
Peso molecular:
116.12
MDL number:
MFCD00039710
UNSPSC Code:
41116105
PubChem Substance ID:
24897824
NACRES:
NA.25

form

solid

Quality Level

100

SMILES string

O=NN1CCOCC1

InChI

1S/C4H8N2O2/c7-5-6-1-3-8-4-2-6/h1-4H2

InChI key

ZKXDGKXYMTYWTB-UHFFFAOYSA-N

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Biochem/physiol Actions

Tumor initiator in rodent liver, trachea, nasal cavity, esophagus, kidney, lung, and thyroid.

Packaging

Bulk package

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H351

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificados de análisis (COA)

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W Lijinsky et al.
Carcinogenesis, 3(8), 911-915 (1982-01-01)
A comparison was made of the carcinogenic effectiveness of some cyclic nitrosamines containing oxygen in the ring. The compounds were administered to F344 rats at approximately equimolar concentrations in drinking water. Nitrosomorpholine, nitroso-1,3-oxazolidine and nitrosotetrahydro-1,3-oxazine were of similar potency and
W Lijinsky et al.
In vivo (Athens, Greece), 5(2), 85-89 (1991-03-01)
A number of nitrosamines that have been studied by administration to rats as solutions in drinking water have been examined by gavage administration of similar doses, for assessment of the role of pharmacokinetics in organ-specific carcinogenesis. Methylnitrosoethylamine was more effective
Jutta Groos et al.
Mathematical biosciences, 202(2), 248-268 (2006-04-11)
Several hypotheses are established to describe the formation and progression of foci of altered hepatocytes (FAH). A common model of hepatocarcinogenesis is the mutation model (MM), which is based on the assumption that cells have to undergo multiple successive changes
A Oberemm et al.
Toxicology and applied pharmacology, 241(2), 230-245 (2009-09-01)
A common animal model of chemical hepatocarcinogenesis was used to examine the utility of transcriptomic and proteomic data to identify early biomarkers related to chemically induced carcinogenesis. N-nitrosomorpholine, a frequently used genotoxic model carcinogen, was applied via drinking water at
Olga Teufelhofer et al.
Electrophoresis, 27(20), 4112-4120 (2006-10-21)
Comparative proteome data of normal and diseased tissue samples are difficult to interpret. Proteins detected in tissues are derived from different cell types and blood constituents. Pathologic or toxicant-induced aberrations may affect the proteome profile of tissues in several ways
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