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Nicotinamide is soluble in DMSO to 100 mM.
N0636
Nicotinamide
BioReagent, suitable for cell culture, suitable for insect cell culture
Sinónimos:
Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP
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About This Item
Fórmula empírica (notación de Hill):
C6H6N2O
Número de CAS:
Peso molecular:
122.12
Beilstein/REAXYS Number:
383619
EC Number:
MDL number:
UNSPSC Code:
12352205
PubChem Substance ID:
NACRES:
NA.75
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Productos recomendados
biological source
synthetic (organic)
Quality Level
product line
BioReagent
assay
≥98% (HPLC)
form
powder
mol wt
Mw 122.12 g/mol
technique(s)
cell culture | insect: suitable
cell culture | mammalian: suitable
color
white
mp
128-131 °C (lit.)
solubility
water: soluble 50 mg/mL, clear, colorless
SMILES string
NC(=O)c1cccnc1
InChI
1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
InChI key
DFPAKSUCGFBDDF-UHFFFAOYSA-N
Gene Information
human ... PARP1(142) , SIRT2(22933)
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General description
Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver.[1] NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival.[2] NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.[3]
Application
Biochem/physiol Actions
Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
302.0 °F - closed cup
flash_point_c
150 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Los clientes también vieron
Nicotinamide, a form of vitamin B3, promotes expansion of natural killer cells that display increased in vivo survival and cytotoxic activity
Frei GM, et al.
Blood, 118, 4035-4035 (2011)
Three-dimensional organoids reveal therapy resistance of esophageal and oropharyngeal squamous cell carcinoma cells
Kijima T, et al.
Cellular and molecular gastroenterology and hepatology, 7(1), 73-91 (2019)
Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors
Romero-Calvo I, et al.
Molecular Cancer Research, molcanres-molca0531 (2018)
The influence of nicotinamide on health and disease in the central nervous system
Fricker RA, et al.
International Journal of Tryptophan Research : IJTR, 11, 1178646918776658-1178646918776658 (2018)
Rapid prototyping of a multilayer microphysiological system for primary human intestinal epithelial culture
Hosic S, et al.
bioRxiv, 400721-400721 (2018)
Artículos
Human pancreatic cancer organoid biobank (PDAC organoids) with various KRAS mutations to aide in 3D cell culture and cancer research applications.
Human pancreatic cancer organoid biobank (PDAC organoids) with various KRAS mutations to aide in 3D cell culture and cancer research applications.
Human pancreatic cancer organoid biobank (PDAC organoids) with various KRAS mutations to aide in 3D cell culture and cancer research applications.
Human pancreatic cancer organoid biobank (PDAC organoids) with various KRAS mutations to aide in 3D cell culture and cancer research applications.
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what is the solubility in DMSO?
1 answer-
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What is the stability of Nicotinamide when lyophilized and in stock solution?
1 answer-
The recommended storage conditions and stability for stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month. Wherever possible, solutions should be made and used on the same day.
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Can Nicotinamide aliquots be freeze-thawed more than once?
1 answer-
The product in solution has not been tested for stability following multiple freeze/thaw cycles. As a general practice, multiple freeze/thaw cycles are avoided.
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How long are aliquots of a 1 M solution in DPBS or water at °70°C stable?
1 answer-
Solution stability studies at 70°C have not been performed on this product. Neutral aqueous solutions are fairly stable and may be autoclaved at 120 °C for up to 20 minutes. Solutions at an alkaline pH will be hydrolyzed to nicotinic acid. Nicotinamide is a component of several vitamin solutions used in cell culture (listed as niacinamide). These products are stored at -20°C, but are typically added to culture medium at 37°C.
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Which is the recomiendes re test date for N0636-100g, lot SLBZ7561? Thank you.
1 answer-
This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
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