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Merck

M1753

Sigma-Aldrich

1-tioglicerol

≥97%

Sinónimos:

α-Monotioglicerol, α-Tioglicerol, 3-Mercapto-1,2-propanodiol

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About This Item

Fórmula lineal:
HSCH2CH(OH)CH2OH
Número de CAS:
Peso molecular:
108.16
Beilstein:
1732046
Número CE:
Número MDL:
Código UNSPSC:
12352201
ID de la sustancia en PubChem:
NACRES:
NA.25
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Nivel de calidad

Ensayo

≥97%

Formulario

liquid

índice de refracción

n20/D 1.527 (lit.)

bp

118 °C/5 mmHg (lit.)

densidad

1.25 g/mL at 25 °C (lit.)

temp. de almacenamiento

2-8°C

cadena SMILES

OCC(O)CS

InChI

1S/C3H8O2S/c4-1-3(5)2-6/h3-6H,1-2H2

Clave InChI

PJUIMOJAAPLTRJ-UHFFFAOYSA-N

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Descripción general

El 1-tioglicerol estimula la síntesis de porfirina en Escherichia coli de crecimiento aerobio. [1] Es un inhibidor de la actividad glicerol cinasa tanto in vitro como in situ .

Aplicación

El 1-tioglicerol se ha utilizado en un estudio para evaluar la manipulación del crecimiento acuoso de nanocristales de CdTe. [2] También se ha utilizado en un estudio en el que se investigaba el efecto de la fijación de superficie sobre la unión de ligandos. [3]

Nota de preparación

Este producto es miscible en etanol (1 ml/ml, 50 %, v/v), produciendo una disolución transparente e incolora. También es miscible en agua (0,1 M).

Pictogramas

Skull and crossbones

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Skin Irrit. 2 - Skin Sens. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

210.2 °F - closed cup

Punto de inflamabilidad (°C)

99 °C - closed cup

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Certificados de análisis (COA)

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Hao Zhang et al.
Journal of the American Chemical Society, 128(31), 10171-10180 (2006-08-03)
The present article is devoted to systematically exploring the influence of various experimental variables, including the precursor concentration, the ligand nature, the counterion type, the Cd-to-Te molar ratio, pH, and temperature, on the aqueous growth of CdTe nanocrystals. The growth
G T Javor et al.
Journal of bacteriology, 174(3), 1072-1075 (1992-02-01)
1-Thioglycerol (TG) stimulates the synthesis of porphyrin in aerobically growing Escherichia coli. Here the levels of delta-aminolevulinate biosynthetic enzymes in untreated and TG-treated E. coli THU and PUC2 (a mutant of THU which overproduces porphyrins in the presence of thiols)
Chun-Jie Guo et al.
Cell, 181(3), 621-636 (2020-04-08)
Long noncoding RNAs (lncRNAs) evolve more rapidly than mRNAs. Whether conserved lncRNAs undergo conserved processing, localization, and function remains unexplored. We report differing subcellular localization of lncRNAs in human and mouse embryonic stem cells (ESCs). A significantly higher fraction of
Sven Hildebrand et al.
Scientific reports, 10(1), 9950-9950 (2020-06-21)
Here, we describe a new immersion-based clearing method suitable for optical clearing of thick adult human brain samples while preserving its lipids and lipophilic labels such as 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI). This clearing procedure is simple, easy to implement, and allowed
P Tengvall et al.
Biomaterials, 17(10), 1001-1007 (1996-05-01)
Thiol-modified surfaces are chemically well defined and suited for surface biological model experiments and biomaterials research. 3-Mercapto-1,2-propanediol (mercaptoglycerol, MG), immobilized on gold, spontaneously binds immunoglobulins from human serum and activates the complement system. The surface-bound complement factors were detected by

Questions

1–4 of 4 Questions  
  1. What could be causing contamination of cell culture experiments while using M1753? Also, how should M1753 be added to the cell culture media?

    1 answer
    1. To avoid contamination, sterile filtration is highly recommended prior to cell culture application. Upon verification, the lab has not formulated a protocol for cell culture use. However, the following citation on M1753 for cell culture application may be of interest as a protocol reference: Im, H. (2011). "Mouse Embryonic Stem Cell Maintenance for Differentiation." Bio-101: e145. DOI: 10.21769/BioProtoc.145.

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  2. What is the concentration of the 1-thioglycerol?

    1 answer
    1. The liquid is not a solution of 1-thioglycerol in some solvent. Rather, it is a neat liquid (i.e., essentially pure 1-thioglycerol). Based on a density of 1.245 g/mL and a molecular weight of 108.2 g/mole, one can calculate an effective molarity of 11.5 M. This information may be found on the M1753 product information sheet.

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  3. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  4. How does the storage temperature relate to shipping conditions?

    1 answer
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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